KIRO® Oncology

Grifols KIRO Oncology is an aseptic compounding robotic system with engineering controls that focus on precision, flexibility, reliability, and safety throughout the highly complex process of compounding chemotherapy medications.


For the compounding of sterile preparations of hazardous drugs.

Benefits of Grifols KIRO Oncology

Patient Safety

  • ISO 5 or better air quality even when opened for cleaning
  • In-process barcode readers and cameras capture product and expiration data on drugs, disposables, and final containers with or without barcodes for verification, accurate traceability, and reduced risk of human error
  • Precision scales perform gravimetric verification at all stages of the compounding process for assurance of dose precision and reporting
  • Avoids cross-contamination by never reusing a disposable for different drugs across different order
  • Adjustable parameters for automatic release of precisely dosed preparations
  • Beyond use dates (BUDs) are automatically assigned and tracked for final products and also for multi-dose vials to ensure maximum utilization, automatic disposal, and waste minimization
  • Tracking, rejection, and final labels can be customized to each facility’s needs

Regulatory Compliance

  • ISO 5 compounding area meets USP <797>, USP <800>, and Current Good Manufacturing Practice (cGMP) regulations on engineering controls for aseptic hazardous compounding
  • Designed as a containment primary engineering control, provides continuous ISO 5 environment during materials loading and automatic compounding
  • Can be properly integrated as a biosafety cabinet in USP <797> and cGMP compliant facilities
  • No turbulence or refluxing at any critical site
  • Sterile products and preparations are not exposed to room air once loaded
  • All processes can be performed without introducing contamination
  • Negative pressure and ACPH are adjustable within USP <800> requirements
  • Included “media fill test cycle” simulates complex preparation for user and device requalifications
  • Searchable, reportable database automatically captures valuable data including ingredient NDC, lot and expiration, precise actual dosing amount, waste and precision relative to order, production time points, user interactions, and BUDs


  • Interface engine supports bidirectional integration with EMR by a variety of protocols including HL7
  • Size - equivalent to a 6-foot vertical flow cabinet—facilitates integration into existing cleanroom facilities
  • Easy to use web-based software application accessible from any workstation with automatic and manual compounding queues, reporting and more.

Staff Protection

  • Protects users and environment from exposure to hazardous drug during critical operations by functioning as a negative-pressure, closed system
  • Compounding area is only open for non-critical material loading and unloading operations, during which it operates as a Class II Biosafety Cabinet
  • Protects users from repetitive stress injuries by automating those that require the most force
  • Protects the user and environment from hazardous waste with integrated systems for automated disposal
  • Self-cleaning process avoids exposure to any potential hazardous drug residue and provides both disinfection and chemical decontamination


  • Two robotic arms enable multiple parallel processes for speed and efficiency
  • Two peristaltic pumps enable fast, precise dosing of diluents
  • Accommodation of a variety of sizes and manufacturers' bags, syringes, infusers, and cassettes — as well as industry-standard disposables — mitigates disruption to current and future contracts and preferences
  • Prepares patient-specific doses and small batches using liquid and lyophilized drugs
  • Partial vials are held within the cabinet and can be automatically used for subsequent dose preparation
  • “Partial vial” labels, database tracking, and recommendations to use available partial vials maximize reuse of unloaded partial vials
  • Automatic disposal of empty vials and used disposables
  • Optimizes workflow efficiencies by freeing user to start picking process for next order or other tasks
  • Self-cleaning process reduces time spent by staff

Download our product brochure for more information about features, regulation compliance and equipment specifications, installation requirements and certifications.

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