Gri-fill® 4 Semi-automatic Compounding Device

Gri-fill 4 is a semi-automatic compounding system for batch and patient-specific production of non-hazardous and hazardous compounded sterile preparations.


Advance patient safety and mitigate repetitive stress injuries with precision and sterility assurance.

Benefits of Grifols Gri-fill 4

Patient Safety

  • Highly precise dosing via volumetric and/or peristaltic pump for automated filling
  • Reduced risks of contamination and human error
  • In-process checks and validation
  • Drug and final container identification by barcode reading

User Safety | Ease of Use

  • Mitigation of repetitive stress and needle-stick injuries
  • Compatibility with closed system drug transfer devices (CSTD)
  • Simple connection to sets and containers
  • Intuitive operation and cleaning procedures

Efficient | Flexible

  • Doses from one or two source solutions, reconstitutes the vial, withdraws it from final container in same cycle of the device
  • Adaptable to different source solution containers (vials, bags, bottles) and to different final containers: Gri-Bag®, bags, syringes, elastomeric pumps, cassettes, etc.
  • Ability to print custom ID labels (patient-specific and batches)


  • Receive preparations and patient information from electronic medical record (EMR) interface
  • Remote access to the Gri-fill from the pharmacist’s computer
  • User authentication centralized Lightweight Directory Access Protocol (LDAP)

Two working modes

  • Stand-alone mode for a single device
  • Centralized mode with up to five Gri-fill devices with a common database Web-based management software
  • Facilitates optimal management of preparation orders
  • Enables real-time tracking of compounded preparations
  • Allows flexible settings via configurable operation parameters
  • Provides preparation reports
  • Delivers full audit trail of the preparation process, user changes and integration events

Compliance | Record Keeping

  • Lot traceability and expiration control
  • Full audit trail of preparation process and changes performed by the user
  • Reporting of preparations and wasted volumes

Download our product brochure for more information about Gri-fill features, Gri-bag and accessories.

Learn more about Robotics and Other Compounding Devices

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