Robotics and Other Compounding Devices
Increase accuracy and control with automation that helps advance patient safety and protect staff during production of hazardous and non-hazardous compounded sterile preparations.
KIRO Oncology
For the compounding of sterile preparations of hazardous drugs.
KIRO SP
For the compounding of sterile preparations of non-hazardous drugs.
- Visibility and greater control of accuracy via gravimetrics, barcode readers, and cameras
- Flexible design: syringes, IV bags, cassettes, and elastomeric pumps
- Enclosed, self-cleaning for staff protection
- Improved efficiency via innovative software and hardware
- EMR interface and multi-device integration
Grifols KIRO Oncology is a robotic system focused on precision, flexibility, reliability, and safety throughout the highly complex process of compounding oncology medications.
Benefits of Grifols KIRO Oncology
Patient Safety
- Precision scales for gravimetric verification at all stages of the compounding process to control dosing accuracy
- In-process barcode readers and cameras identify drugs, disposables, and final containers to document traceability
Staff Protection
- Self-cleaning process avoids manual cleaning
- Automated compounding and self-cleaning occur in a completely enclosed environment
- Integrated system for automatic disposal of hazardous waste into self-contained enclosed
- Operators are protected from repetitive stress injuries
Regulatory Compliance
- Compliance with USP and GMP regulations supported by standardizing aseptic procedures, facilitating personnel and process qualification, and minimizing risk of exposure when preparing hazardous drugs
- Airflow operation and temperature control, and optional continuous particle counter to meet GMP requirements
- Fully serviced during deployment, qualification, and periodic maintenance, including dosing accuracy tests and air flow certifications addressing smoke tests under dynamic conditions for USP <797> compliance
- Syringes can be automatically capped with CSTDs and infusion bags loaded with a pre-attached CSTD spike to supply closed containers and meet USP <800> requirements for the administration of hazardous drugs
- KIRO Oncology meets electrical safety requirements by being UL listing marked per IEC 61010 and EMC certifi ed per IEC 61326-1
Flexibility and Efficiency
- Supports a wide variety of vials and final containers
- Prepares patient-specific doses and small batches using liquid or lyophilized drugs
- Device and user efficiency increased by allowing identification and labeling of materials by the user during automatic compounding
- Software guided combination, replacement and reuse of vials for optimal drug use including partially used vial tracking and labeling
- Workflow optimized by visual planning board
- Configuration options to respond to specific compounding practices, workflows, and clinical needs
KIRO SP is a KIRO Oncology robot used for the automated production of compounded sterile preparations of nonhazardous doses. It is particularly well-suited for specialized and/or complex dose preparations requiring an exceptionally high degree of accuracy.
Benefits of Grifols KIRO SP
Patient Safety
- Barcode scanning for reduced risk of human error
- A linear camera for visual control of labels
- Batch and expiration date control for safety
- Double gravimetric control helps to ensure accuracy
- Reports on database records
Staff Safety
- Compounding in an enclosed environment
- Self-cleaning
- Automated waste disposal
Operational Benefits
- Manages partially used vials
- Accommodates various sizes and manufacturers of vials and syringes
- Two coordinated robotic arms for higher speed during complex preparations
- Two peristaltic pumps enable fast, accurate dosing of diluents
- Robust and intuitive user interface
- Order selection (manual or automated)
- Patient-specific (patient view)
- Standard dose (product view)
- Label printing with customizable templates
- Partial vial management (internal and external)
- Media fill cycles
- Self-cleaning
- Vision system
- Technical assistance
KIRO® Fill Automated Compounding Device
- High throughput syringe filling of non-hazardous sterile preparations
- Automation of key critical and repetitive processes such as capping and filling to ensure consistency
- Unique design allows loading, unloading, and compounding to occur simultaneously
- Small footprint comparable to a standard six foot laminar flow hood
KIRO Fill is an automated compounding device designed to enhance dosing accuracy and optimize operational efficiencies during the production of non-hazardous compounded sterile preparations.
Benefits of KIRO Fill
Safety
- ISO 5 aseptic compounding environment protects sterility during production of non-hazardous compounded sterile preparations
- Automation minimizes risk of contamination and increases dosing accuracy
- Repetitive stress and needle-stick injuries are mitigated
- Guided and software controlled manual loading and unloading of supplies for enhanced patient safety
Control and Traceability
- Loading and automated compounding processes are controlled by means of barcode scanning and RFID identification
- Batch reports automatically generated to ensure traceability through production, including environmental monitoring data
Flexibility and Efficiency
- Unique design and small footprint facilitate high throughput and optimization of workload, workflow, and staff time while consuming minimal valuable cleanroom space
- Integrates two automated units working in parallel
- Accommodation of a large variety of sizes and types of source and final containers
- Batch and patient-specific compounded sterile preparations
- Optimized use of medication and left-overs
Regulatory Compliance
- Compliance with USP and GMP regulations supported by standardizing aseptic procedures, facilitating personnel and process qualification
- Air flow operation, temperature control, and continuous particle counter to meet GMP requirements
- Fully serviced during deployment, qualification, and periodic maintenance, including dosing accuracy tests and air flow certifications addressing smoke tests under dynamic conditions for USP <797> compliance
- KIRO Fill meets electrical safety requirements by being UL listing marked per IEC 61010 and EMC certified per IEC 61326-1
Gri-fill® 4 Semi-automatic CompoundingDevice and Gri-bag
Advance patient and user safety, optimize operational efficiencies, and increase flexibility during batch and patient-specific production of non-hazardous and hazardous compounded sterile preparations.
Gri-fill® 4.0
Gri-fill 4 is a uniquely designed, semi-automated system for compounding a variety of intravenous mixtures, including chemotherapy doses, to advance patient safety and mitigate repetitive stress injuries with precision and sterility assurance.
- Highly precise dosing via volumetric and/or peristaltic pump for automated filling
- Adaptable to different source solution containers (vials, bags, bottles) and to different final containers: Gri-Bag®, bags, syringes, elastomeric pumps, cassettes, etc.
- Self-calibrating
- Compact footprint
- Easy to install
Gri-Bag
- Sterile, disposable bags in multiple sizes
- Sterilizing filter and integrity test for confirmation of sterility integral to each bag
Gri-fill® 4 Key Benefits
Patient Safety
- Highly precise dosing via volumetric and/or peristaltic pump for automated filling
- Reduced risks of contamination and human error
- In-process checks and validation
- Barcoded drug verification
User Safety | Ease of Use
- Mitigation of repetitive stress and needle-stick injuries
- Compatibility with closed system drug transfer devices
- Simple connection to sets and containers
- Intuitive operation and cleaning procedures
Compliance | Record Keeping
- Lot traceability and expiration control
- Full audit trail of preparation process and changes performed by the user
- Reporting of preparations and wasted volumes
Efficient | Flexible
- Doses from one or two source solutions, reconstitutes the vial, withdraws it from final container in same cycle
- Fits easily inside a standard laminar airflow hood or biosafety cabinet
- Adaptable to different source solution containers (vials, bags, bottles) and to different final containers: Gri-Bag®, bags, syringes, elastomeric pumps, cassettes, etc.
- Ability to print custom ID labels (patient-specific and batches)
Gri-Bag
The Gri-fill system, when used in conjunction with Gri-Bag, passes each drug dose through a 0.2 μm filter incorporated in the bag and performs an integrity test on each unit after dosing. Thus, Gri-fill ensures that sterility is maintained throughout the compounding process.
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