Grifols KIRO Oncology Automated Compounding Device

KIRO Oncology

For the compounding of sterile preparations of hazardous drugs.


For the compounding of sterile preparations of non-hazardous drugs.

  • Visibility and greater control of accuracy via gravimetrics, barcode readers, and cameras
  • Flexible design: syringes, IV bags, cassettes, and elastomeric pumps
  • Enclosed, self-cleaning for staff protection
  • Improved efficiency via innovative software and hardware
  • EMR interface and multi-device integration

Click to show product details

Click to hide product details

Grifols KIRO Oncology is a unique robotic system with engineering controls that focus on precision, flexibility, reliability, and safety throughout the highly complex process of compounding chemotherapy medications.

Benefits of Grifols KIRO Oncology

Patient Safety

  • Precision scales perform gravimetric verification at all stages of the compounding process for assurance of dose accuracy
  • In-process barcode readers and cameras capture data on drugs, disposables, and final containers with or without barcodes for accurate traceability
  • Accuracy is calculated for automatic error rejection and reporting
  • Beyond use dates (BUDs) are automatically calculated and tracked for final products and multi-dose vials to ensure maximum fluid removal, automatic disposal, and waste minimization

Staff Protection

  • Self-cleaning process mitigates exposure to hazardous drugs and chemicals
  • The cabinet is only opened for loading and unloading, protecting operators from repetitive stress injuries and exposure to hazardous drugs
  • Automated compounding and self-cleaning occur in a completely enclosed environment offering unparalleled protection for staff

Regulatory Compliance

  • ISO 5 compounding area meets USP <797> standards and relevant Good Manufacturing Processes (GMPs) for patient safety
  • Designed to meet <USP 800> standards for operator and environment protection from unintended exposure to hazardous drugs during loading and unloading.
  • Searchable, reportable database automatically captures valuable data


  • Two robotic arms enable vial reconstitution and bag filling in parallel
  • High-precision drug and diluent pumps maximize reliability of dosing success
  • Accommodation of a variety of sizes and manufacturers' bags, syringes, infusers, and cassettes—as well as industry-standard disposables—mitigates disruption to current contracts and preferences
  • Prepares patient-specific doses and small batches using liquid and lyophilized drugs
  • Partially used vials are held within the cabinet and can be automatically used for subsequent dose preparation
  • Partial-vial labels, database tracking, and intelligent alerts maximize reuse of unloaded partial vials
  • Design optimizes workflow efficiencies and minimizes risks of repetitive task injuries
  • Integrated system for secure disposal of hazardous waste without compromising the cabinet or cleanroom environment


  • Interface engine supports bidirectional messaging with many protocols, including HL7
  • Size—equivalent to a 6-foot vertical flow cabinet—facilitates integration into existing cleanroom facilities


KIRO SP is a KIRO Oncology robot used for the automated production of compounded sterile preparations of nonhazardous doses. It is particularly well-suited for specialized and/or complex dose preparations requiring an exceptionally high degree of accuracy.


Benefits of Grifols KIRO SP

Patient Safety

  • Barcode scanning for reduced risk of human error
  • A linear camera for visual control of labels
  • Batch and expiration date control for safety
  • Double gravimetric control helps to ensure accuracy
  • Reports on database records

Staff Safety

  • Compounding in an enclosed environment
  • Self-cleaning
  • Automated waste disposal

Operational Benefits

  • Manages partially used vials
  • Accommodates various sizes and manufacturers of vials and syringes
  • Two coordinated robotic arms for higher speed during complex preparations
  • Two peristaltic pumps enable fast, accurate dosing of diluents
  • Robust and intuitive user interface
  • Order selection (manual or automated)
  • Patient-specific (patient view)
  • Standard dose (product view)
  • Label printing with customizable templates
  • Partial vial management (internal and external)
  • Media fill cycles
  • Self-cleaning
  • Vision system
  • Technical assistance
Grifols KIRO Fill

KIRO® Fill Automated Compounding Device

  • High throughput syringe filling of non-hazardous sterile preparations
  • Automation of key critical and repetitive processes such as capping and filling to ensure consistency
  • Unique design allows loading, unloading, and compounding to occur simultaneously
  • Small footprint comparable to a standard six foot laminar flow hood

Click to show product details

Click to hide product details

KIRO Fill is an automated compounding device designed to enhance dosing accuracy and optimize operational efficiencies during the production of non-hazardous compounded sterile preparations.

Benefits of KIRO Fill

Patient Safety

  • ISO 5 aseptic compounding environment protects sterility during production of non-hazardous compounded sterile preparations
  • Automation minimizes risk of contamination and increases dosing accuracy
  • Touchscreen guided manual loading and unloading of supplies designed to avoid errors

Staff Protection

  • Automated filling reduces the risk of repetitive stress injuries
  • Automatic capping with tamper evident caps helps mitigate potential needle stick injuries

Control and Traceability

  • Loading and automated compounding processes are controlled by means of barcode scanning and RFID identification
  • Batch reports are automatically generated to ensure traceability through production, including environmental monitoring data

Flexibility and Efficiency

  • Unique design integrates two automated units working in parallel to facilitate high throughput (100-150 syringes per hour) to improve efficiency and optimize workflow
  • Up to 20 loading positions for syringes (including 3 mL, 5 mL, 10 mL, 20 mL, 30 mL, and 60mL)
  • Small footprint preserves valuable cleanroom space
  • Optimizes use of medication and management of excess

Regulatory Compliance

  • Compliance with USP and GMP regulations supported by standardizing aseptic procedures, facilitating personnel and process qualification
  • Continuous air flow, temperature, and particle monitoring to meet GMP requirements
  • Fully serviced during deployment, qualification, and periodic maintenance, including dosing accuracy tests and air flow certifications addressing smoke tests under dynamic conditions for USP <797> compliance
  • KIRO Fill meets electrical safety requirements by being UL listing marked per IEC 61010 and EMC certified per IEC 61326-1
Grifols Gri-fill device for automatic IV compounding

Gri-fill 3.0 Sterile Compounding
System and Gri-bag

Advance patient safety and mitigate repetitive stress injuries with precision and sterility assurance.

Gri-fill® 3.0

  • Prepares batches and patient-specific doses
  • Accommodates syringes, IV bags, vials, bottles, cassettes, and infusers
  • Precise dosing with volumetric pump
  • Compact footprint


  • Sterile, disposable bags in multiple sizes
  • Sterilizing filter and integrity test for confirmation of sterility integral to each bag
Grifols Gri-fill device for automatic IV compounding

Click to show product details

Click to hide product details

Gri-fill 3.0 is designed to advance efficiencies and quality during the compounding of any type of intravenous mixture (including chemotherapy).

Gri-fill 3.0 is compact, easy to install, and easily adaptable to the workflow of intravenous mixtures compounding.

Benefits of Gri-fill 3.0

Patient Safety

  • Sterility assurance using Gri-Bag®
  • Precise dosing with volumetric pump
  • Reduced risk of microbial contamination
  • Lot traceability and expiration control
  • In-process checks and validation

User Safety

  • Avoids repetitive strain injuries
  • Reduced risk of occupational exposure
  • Needle-free

Efficient, Flexible, and Easy to Use

  • Automatic filling and drug reconstitution
  • Fits comfortably inside a standard laminar airflow hood or biosafety cabinet, without hindering its proper functioning
  • Simple connection to sets and containers
  • Easy to clean
  • Adaptable to different source solution containers (vials, bags, bottles) and to different final containers (Gri-Bag, bags, syringes, elastomeric pumps, cassettes, etc.)


The Gri-fill system, when used in conjunction with Gri-Bag, passes each drug dose through a 0.2 μm filter incorporated in the bag and performs an integrity test on each unit after dosing. Thus, Gri-fill ensures that sterility is maintained throughout the compounding process.

Grifols is committed to providing you with the solutions you need.
Please contact us for more information.